This study was planned to investigate during which procedure, how often, and when the injury with sharp instruments and needle sticks devices occur, and to provide an insight for the studies relevant to the precautions that can be taken to avoid these injuries. It is intended to focus the attention of the OR staff and hospital administrators to the importance of the issue. Methodology: A descriptive study. Participation of 37 nurses and 42 operators working in the OR of a state hospital. A total of 2, 499 operations conducted between September 1 and December 31, 2010, were included; 240 operations had injuries experienced which were included in the study. Questionnaire included 11 questions regarding demographic characteristics and 20 questions to investigate how often injury with sharp instruments and needle sticks devices occurred. The data were evaluated with ěSPSS 17î statistics package program on computer. Mean and percentage values were used to evaluate the data, Chi-Square Test was used for comparison of groups, and Odd Ratio analysis was used to determine person or group specific odds ratios. Significance level was considered to be p=0.05.It was determined that the injuries occurred at most during suturing (48.3%), with suture needle (58.7%), and in cutaneous/subcutaneous tissues (28.3%), during finishing step of the operation (49.1%); injury occurred in assisting peers (42.9%) and at most as self-injury (63.7%).